Education

Career Profile

Research Interests / Specialization

 Molecular association between metabolic syndrome and prostatic diseases.

Pharmacological evaluations and toxicity assessment of novel chemicals and drugs.

Teaching Experience (Subjects/Courses Taught)

None.

Honors & Awards

2005- Prof. K. Subhramanyam award for “Best student in Medicinal Chemistry and Pharmacology.

2005- Qualified GATE in pharmaceutical sciences (All India 43rd Rank; 99.62 percentile)

2005- NIPER fellowship during M. S. (Pharm) programme

2005-M. Tech in Biotechnology (All India 1st Rank, , declined to take admission)

2007- Qualified LS UGC-NET in Life Sciences

2007-20011- NIPER Fellowship during PhD programme

Publications

1.

A. Vikram and G. B. Jena, Diet-induced hyperinsulinemia accelerates growth of human androgen independent PC-3 cells. Nutrition and Cancer. xx (2011) xxx-xxx. (Imp. Fact. 2.1)

2.

A. Vikram, S. Kushwaha and G. B. Jena, Relative influence of testosterone and insulin on the prostatic cell proliferation and growth. Steroids. 76 (2011) 416-423. (Imp. Fact. 2.9)

3.

A. Vikram, G. B. Jena and P. Ramarao, Insulin resistance reduces botulinum neurotoxin-type A induced prostatic atrophy and apoptosis in rats. European Journal of Pharmacology, 650 (2011) 356-363. (Imp. Fact. 2.6, Sco. Citat.2)

4.

A. Vikram and G. B. Jena, Role of insulin and testosterone in prostatic growth: Who is doing what? Medical Hypotheses, 76 (2011) 474-478. Hypothesis, (Imp. Fact. 1.4, Sco. Citat.1)

5.

C. Gupta, A. Vikram, D. N. Tripathi, P. Ramarao and G. B. Jena, Quercetin inhibits Diethylnitrosamine induced hepatic preneoplastic lesions in rat. Nutrition and Cancer, 63 (2011) 234-241. (Imp. Fact. 2.1)

6..

S. C. Mandal, D. N. Tripathi, A. Vikram, P. Ramarao and G. B. Jena, Furosemide-induced oxidative stress, genotoxicity and cytotoxicity in mice hepatocytes but weak genotoxicity in the bone marrow cells. Fundamental and Clinical Pharmacology. xx (2011) xxx-xxx. (Imp. Fact. 2.4)

7.

S. Kushwaha, A. Vikram and G. B. Jena, Protective effects of enalapril in streptozotocin-induced diabetic rat: Studies with DNA damage, apoptosis and expression of CCN2 in heart, kidney and liver. Journal of Applied Toxicology, xx (2011) xxx-xxx. (Imp. Fact. 2.1)

8.

A. Mughal, A. Vikram, S. Kushwaha and G. B. Jena, Simultaneous use of erythropoietin and prior bleeding enhances sensitivity of peripheral blood micronucleus assay. Mutagenesis, 26 (2011) 331-338. (Imp. Fact. 3.5)

9.

A. Vikram, G. B. Jena and P. Ramarao, Pioglitazone attenuates prostatic enlargement in diet induced insulin-resistant rats by altering lipid distribution and reversing hyperinsulinemia. British Journal of Pharmacology, 161 (2010) 1708-1721. (Imp. Fact. 5.2, Sco. Citat.3)

10.

A. Vikram and G. B. Jena, S961, an insulin receptor antagonist causes hyperglycemia, hyperinsulinemia, insulin-resistance and depletion of energy stores in rats. Biochemical Biophysical Research Communications, 398 (2010) 260-265. (Imp. Fact. 2.6, Sco. Citat.1)

11.

A. Vikram, G. B. Jena and P. Ramarao, Insulin resistance and benign prostatic hyperplasia: the connection. European Journal of Pharmacology, 641 (2010) 75-81. Review, (Imp. Fact. 2.6, Sco. Citat.4)

12.

A. Vikram, G. B. Jena and P. Ramarao, Increased cell proliferation and contractility of prostate gland in insulin-resistant rats: Linking hyperinsulinemia with prostatic hyperplasia. Prostate, 1 (2010) 79-89. (Imp. Fact. 3.1, Sco. Citat.12),

13.

G. B. Jena, A. Vikram, D. N. Tripathi and P. Ramarao, Use of chemoprotectants in chemotherapy and radiation therapy: Challenges in the selection of antioxidants. Integrative Cancer Therapy, 9 (2010) 253-258. Commentary, (Imp. Fact. 1.5, Sco. Citat.0)

14.

C. Gupta, A. Vikram, D. N. Tripathi, P. Ramarao and G. B. Jena, Antioxidant and antimutagenic effect of quercetin against DEN induced hepatotoxicity in rat. Phytotherapy Research, 24 (2010) 119-128. (Imp. Fact. 1.9, Sco. Citat.4)

15.

A. Mughal, A. Vikram, P. Ramarao and G. B. Jena, Micronucleus and comet assay in the peripheral blood of juvenile rats: Relationship between assay sensitivity and time of sampling. Mutation Research. 700 (2010) 86-94. (Imp. Fact. 2.6, Sco. Citat.1)

16.

V. P. Dadhania, D. N. Tripathi, A. Vikram, P. Ramarao and G. B. Jena, Intervention of alpha-lipoic acid ameliorates Methotrexate induced gastrointestinal toxicity in SD rats. Chemico-Biological Interaction, 183 (2010) 85-97. (Imp. Fact. 2.5, Sco. Citat.2)

17.

S. Kushwaha, D. N. Tripathi, A. Vikram, P. Ramarao and G. B. Jena, Evaluation of multi-organ DNA damage by comet assay from 28 days repeated dose oral toxicity test in mice: A practical approach for test integration in regulatory toxicity testing. Regulatory Toxicology and Pharmacology, 58 (2010) 145-154. (Imp. Fact. 1.8, Sco. Citat.0)

18.

A. A. Pawar, A. Vikram, D. N. Tripathi, S. Padmanabhan, P. Ramarao and G. B. Jena, Anti-genotoxic effects of acetyl- and thio- analogue of salicylic acid against Mitomycin C induced genotoxicity. In vivo, 23 (2009) 303-307. (Imp. Fact. 1.1, Sco. Citat.0)

19.

K. Saandeep, A. Vikram, D. N. Tripathi, P. Ramarao and G. B. Jena, Influence of hyperglycemia on chemical-induced Toxicity: Study with cyclophosphamide in rat. Basic and Clinical Pharmacology and Toxicology, 105 (2009) 236-242. (Imp. Fact. 2.3, Sco. Citat.0)

20.

S. Padmanabhan, D. N. Tripathi, A. Vikram, P. Ramarao and G. B. Jena, Cytotoxic and genotoxic effects of methotrexate in germ cells of male swiss mice. Mutation Research, 655 (2009) 59-67. (Imp. Fact. 2.5, Sco. Citat.5)

21.

S. Padmanabhan, D. N. Tripathi, A. Vikram, P. Ramarao and G. B. Jena, Methotrexate induced cytotoxicity and genotoxicity in germ cells of mice: Intervention of folic and folinic acid. Mutation Research, 673 (2009) 43-52. (Imp. Fact. 2.6, Sco. Citat.8)

22.

A. Vikram, D. N. Tripathi, A. A. Pawar, P. Ramarao and G. B. Jena, Pre-bled-young-rats in genotoxicity testing: A model for peripheral blood micronucleus assay. Regulatory Toxicology and Pharmacology, 52 (2008) 147-15. (Imp. Fact. 1.8, Sco. Citat.3)

23.

A. Vikram, D. N. Tripathi, P. Ramarao and G. B. Jena, Intervention of D-glucose ameliorates the toxicity of streptozotocin in accessory sex organs of rat. Toxicology and Applied Pharmacology, 226 (2008)84-93. (Imp. Fact. 3.5, Sco. Citat.15)

24.

D. N. Tripathi, A. A. Pawar, A. Vikram, P. Ramarao and G. B. Jena, Use of Alkaline comet assay for the detection of transplacental genotoxins in new born mice. Mutation Research, 653 (2008) 134-13. (Imp. Fact. 2.6, Sco. Citat.5)

25.

A. Vikram, P. Ramarao and G. B. Jena, Prior bleeding enhances the sensitivity of peripheral and bone marrow micronucleus test in rat. Mutagenesis, 22 (2007)287-291. (Imp. Fact. 3.5, Sco. Citat.7)

26.

A. Vikram, D. N. Tripathi, P. Ramarao and G. B. Jena, Evaluation of streptozotocin genotoxicity in rats from different ages using the micronucleus assay. Regulatory Toxicology and Pharmacology, 49 (2007)238-244. (Imp. Fact. 1.8, Sco. Citat.12)

Languages

Hindi (Native Language) and English.

Patents

None.

Professional Memberships

British Pharmacological Society (BPS) and American Society for Pharmacology and Experimental

Therapeutics (ASPET)

Scientific Meetings

1.

A. Vikram, P. Ramarao and G. B. Jena, Insulin-resistance associated hyperinsulinemia activates MEK/ERK signaling and promotes prostatic growth: Reversal of effect with the intervention of PPARg agonist pioglitazone. Experimental Biology-2011, Washington DC, USA.

2.

A. Vikram, Pre-bled-young-rats as a model for peripheral blood micronucleus assay the in genotoxicity testing, 28th annual conference of Society of Toxicology (STOX), Guru Angaddev university Ludhuiana (2008).

3.

A. Vikram, D. N. Tripathi, A. A. Pawar, P. Ramarao and G. B. Jena, Induction of micronuclei by Streptozotocin in rat: Influence of different factors. All India Conference on Cell Biology, Delhi.

4.

D. N. Tripathi, A. Vikram, and G. B. Jena, Use of comet assay for the detection of transplacental genotoxins. Indian Pharmacological society (IPS - 2007), NIPER Mohali.

5.

G. B. Jena, D. N. Tripathi, P. Ramarao and A. Vikram, Juvenile animal genotoxicity studies: A regulatory requirement. Indian Pharmacological society (IPS - 2007), NIPER Mohali.

6..

A. Mughal, A. Vikram and G. B. Jena, Correlation of DNA damage in the peripheral blood of juvenile rat: Assay sensitivity and mechanism. 35th Annual conference of Environmental Mutagen society of India and International Symposium on Mutagens and Genetic Diversity for Health and Agriculture (EMSI-2010), Punjab University Chandigarh.

7.

S. Kushwaha, A. Vikram and G. B. Jena, Enalapril attenuates DNA damage, apoptosis and expression of CCN2 in the heart, kidney and liver of streptozotocin-induced diabetic rat. 30th Annual Conference of Society of Toxicology (STOX), Jamia Hamdard, Delhi.